I do use Vise Hada Patch tape on my thumb. One benefit is a protection from skin abrasions, but I believe proper fit and proper release should eliminate blisters and calluses. Vise's tag line is "Feels better on your hand than your own skin." I have to admit, I do like the feel of the tape, but the main reason I use Vise tape on my hand is to provide a consistent friction at release. Weather in Arkansas changes pretty often (it is going to be 65 today), sometimes your thumb feels slick, sometimes tacky; but with the tape I can rely on the same feel at release. With the tape, your thumb release will be a little quicker. I had to adjust my thumb pitch forward to prevent some squeezing. I can assist you on choosing the right tape; and when you find you like bowling with Vise's performance tape, I can double check your fit for that perfect release.